| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261395 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9660920 |
Exportin-t Is Predominantly Nuclear, Binds NPCs, and Shuttles Rapidly between Nucleus and Cytoplasm. RanGTP appears to have at least two functions in this complex. First, it stabilizes the tRNA/exportin-t interaction (see Figure 4B). Second, exportin-t apparently has to bind RanGTP for rapid exit from the nucleus . RanGTP causing a conformational change in exportin-t, which increases the affinity for export sites at the NPC. Exportin-t probably makes a direct contact to the NPC and accounts for the interactions that drive translocation of the tRNA/exportin-t/RanGTP complex out of the nucleus. |
|
3.0
Nuclear_pore_function
