| + |
BRCA1-C complex | up-regulates 
|
G2/M_transition-checkpoint |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263229 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16391231 |
This result implies that the BRCA1/BARD1–RMN–CtIP complex is required for activation of the G2/M checkpoint. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DCK | up-regulates
|
G2/M_transition-checkpoint |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275806 |
|
|
|
|
| pmid |
sentence |
| 27879648 |
Deoxycytidine kinase (dCK) is a key enzyme in deoxyribonucleoside salvage and the anti-tumor activity for many nucleoside analogs. dCK is activated in response to ionizing radiation (IR)-induced DNA damage and it is phosphorylated on Serine 74 by the Ataxia-Telangiectasia Mutated (ATM) kinase in order to activate the cell cycle G2/M checkpoint. |
|
| Publications: |
1 |
4.0
G2/M_transition-checkpoint