| + |
BRCA1-BARD1 complex | form complex 
binding
|
BRCA1-C complex |
0.805 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263222 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
The BRCA1–C complex consisting of BRCA1, Mre11:Rad50:Nbs1 (collectively known as the MRN complex) and CtIP plays a role in DSB end resection, a process that also involves EXO1 and DNA2 |
|
| Publications: |
1 |
| + |
BRCA1-C complex | up-regulates 
|
G2/M_transition-checkpoint |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263229 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16391231 |
This result implies that the BRCA1/BARD1–RMN–CtIP complex is required for activation of the G2/M checkpoint. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBBP8 | form complex
binding
|
BRCA1-C complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263220 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
The BRCA1–C complex consisting of BRCA1, Mre11:Rad50:Nbs1 (collectively known as the MRN complex) and CtIP plays a role in DSB end resection, a process that also involves EXO1 and DNA2|The interaction between BRCA1 and CtIP within this complex is mediated by CDK‐dependent phosphorylation of CtIP‐S327 |
|
| Publications: |
1 |
| + |
zinc(2+) | form complex
binding
|
BRCA1-C complex |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269478 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
The BRCA1–C complex consisting of BRCA1, Mre11:Rad50:Nbs1 (collectively known as the MRN complex) and CtIP plays a role in DSB end resection, a process that also involves EXO1 and DNA2 |
|
| Publications: |
1 |
| + |
MRE11/RAD50/NBS1 | form complex
binding
|
BRCA1-C complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263221 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
The BRCA1–C complex consisting of BRCA1, Mre11:Rad50:Nbs1 (collectively known as the MRN complex) and CtIP plays a role in DSB end resection, a process that also involves EXO1 and DNA2 |
|
| Publications: |
1 |
| + |
BRCA1-C complex | up-regulates
|
DNA_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263228 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
The BRCA1–C complex consisting of BRCA1, Mre11:Rad50:Nbs1 (collectively known as the MRN complex) and CtIP plays a role in DSB end resection, a process that also involves EXO1 and DNA2 |
|
| Publications: |
1 |
| + |
manganese(2+) | form complex
binding
|
BRCA1-C complex |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269476 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
The BRCA1–C complex consisting of BRCA1, Mre11:Rad50:Nbs1 (collectively known as the MRN complex) and CtIP plays a role in DSB end resection, a process that also involves EXO1 and DNA2 |
|
| Publications: |
1 |
| + |
double-stranded DNA | form complex
binding
|
BRCA1-C complex |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269477 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
The BRCA1–C complex consisting of BRCA1, Mre11:Rad50:Nbs1 (collectively known as the MRN complex) and CtIP plays a role in DSB end resection, a process that also involves EXO1 and DNA2 |
|
| Publications: |
1 |
| + |
BRCA1-C complex | up-regulates activity 
relocalization
|
TP53BP1 |
0.611 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263230 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
Additional to the role of the BRCA1–C complex in 53BP1 repositioning and initiation of resection, end resection is extended to facilitate RPA loading and subsequent RPA‐Rad51 exchange prior to sister strand invasion |
|
| Publications: |
1 |
3.0
BRCA1-C complex
CPX-4441