| + |
TNFRSF13C | up-regulates 
|
B_cell_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204361 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 24432023 |
Non-canonical nf-kb signaling initiated by baff influences b cell biology at multiple junctures. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
RELB | up-regulates
|
B_cell_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263655 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26385063 |
We have shown here for the first time the role of RelB on lymphocyte development in humans. In the absence of RelB, B cells development is arrested, resulting in poor production of immunoglobulins and specific antibodies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
IKZF3 | up-regulates activity
|
B_cell_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259952 |
|
|
Mus musculus |
Lymphoid Progenitor Cell |
| pmid |
sentence |
| 14718515 |
Here we show that the Ikaros family member, Aiolos, is specifically required for the generation of these plasma cells. Failure to generate high affinity plasma cells in the BM and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos−/− mice with a range of hapten concentrations. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CD19 | up-regulates
|
B_cell_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242888 |
|
|
Mus musculus |
B-lymphocyte |
| pmid |
sentence |
| 25673924 |
CD19 is a crucial regulator of B cell activation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection |
| + |
LTBR | up-regulates
|
B_cell_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156899 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17633025 |
The lymphotoxin-beta receptor (ltbetar, tnfrsf3) signaling pathway activates gene transcription programs and cell death important in immune development and host defense. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
3.0
B_cell_maturation