| + |
Actin_cytoskeleton_reorganization | up-regulates 
|
Dendritic_spine_morphogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266596 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14684878 |
Dendritic spines are small protrusions found on dendrites of principal neurons of mammalian brain. Serving as postsynaptic compartments for individual excitatory inputs, spines show rapid movements and shape changes that are influenced by synaptic activity. The structural modifications of spines are believed to represent morphological correlates of synaptic plasticity. The form and motility of spines are determined mainly by the actin cytoskeleton |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTTN | up-regulates
|
Dendritic_spine_morphogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266595 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14684878 |
Cortactin is an F-actin binding protein and activator of the Arp2/3 actin nucleation machinery that also interacts with the postsynaptic density (PSD) protein Shank. Cortactin is concentrated in dendritic spines of cultured hippocampal neurons, and the N-terminal half of the protein containing the Arp2/3 and F-actin binding domains is necessary and sufficient for spine targeting. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TANC2 | up-regulates 
|
Dendritic_spine_morphogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266897 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 21068316 |
In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. our results indicate that TANC-dependent spine/synapse maintenance requires TANC binding to PSD-95, which promotes synaptic localization of TANC proteins. Thus, it is likely that interaction with PSD-95 concentrates TANC proteins at synapses, where they play a role in mediating PSD-95-dependent maintenance of spines and synapses. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
TANC1 | up-regulates
|
Dendritic_spine_morphogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266896 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 21068316 |
In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. our results indicate that TANC-dependent spine/synapse maintenance requires TANC binding to PSD-95, which promotes synaptic localization of TANC proteins. Thus, it is likely that interaction with PSD-95 concentrates TANC proteins at synapses, where they play a role in mediating PSD-95-dependent maintenance of spines and synapses. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
F-actin_assembly | up-regulates
|
Dendritic_spine_morphogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266597 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14684878 |
Dendritic spines are small protrusions found on dendrites of principal neurons of mammalian brain. Serving as postsynaptic compartments for individual excitatory inputs, spines show rapid movements and shape changes that are influenced by synaptic activity. The structural modifications of spines are believed to represent morphological correlates of synaptic plasticity. The form and motility of spines are determined mainly by the actin cytoskeleton |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ANKRD11 | up-regulates
|
Dendritic_spine_morphogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266730 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
We found that Ankrd11 knockdown disrupted dendrite and spine formation in developing pyramidal neurons. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
3.0
Dendritic_spine_morphogenesis