| + |
ANKRD11 | up-regulates 
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266733 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
We showed that ANKRD11 regulates dendrite outgrowth, arborization, and spine formation via Trkb transcription and activation of its downstream effectors in the developing mouse brain. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
ANKRD11 | up-regulates quantity by expression 
transcriptional regulation
|
NTRK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266731 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
Ankrd11 knockdown decreases the levels of bdnf and Trkb mRNAs. Next, we examine whether ANKRD11 accesses the Trkb promoter in cortical neurons. We performed the chromatin immunoprecipitation assay (ChIP) using an ANKRD11 antibody followed by PCR to amplify the Trkb promoter region. We found that ANKRD11 binds to the Trkb promoter (Fig. 6E). As expected, the level of ANKRD11 binding was decreased in the Ankrd11 knockdown condition. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
ANKRD11 | up-regulates quantity by expression
transcriptional regulation
|
RAB13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266738 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
Neurite growth-related genes such as Trkb, Bdnf, Gap43, Coronin 1B, and Rab13 are downregulated in ANKRD11-deficient neurons. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
ANKRD11 | up-regulates quantity by expression
transcriptional regulation
|
GAP43 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266736 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
Neurite growth-related genes such as Trkb, Bdnf, Gap43, Coronin 1B, and Rab13 are downregulated in ANKRD11-deficient neurons. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
TP53 | up-regulates quantity by expression
transcriptional regulation
|
ANKRD11 |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266735 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 18840648 |
Ankyrin repeat domain 11, ANKRD11 (also known as ANR11 or ANCO1), was found to be a novel p53-interacting protein that enhanced the transcriptional activity of p53. In addition, ANKRD11 itself was found to be a novel p53 target gene. These findings demonstrate a role for ANKRD11 as a p53 coactivator and suggest the involvement of ANKRD11 in a regulatory feedback loop with p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ANKRD11 | up-regulates
|
Dendritic_spine_morphogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266730 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
We found that Ankrd11 knockdown disrupted dendrite and spine formation in developing pyramidal neurons. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
ANKRD11 | up-regulates quantity by expression
transcriptional regulation
|
BDNF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266732 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
Neurite growth-related genes such as Trkb, Bdnf, Gap43, Coronin 1B, and Rab13 are downregulated in ANKRD11-deficient neurons. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
ANKRD11 | up-regulates quantity by expression
transcriptional regulation
|
CORO1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266737 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
Neurite growth-related genes such as Trkb, Bdnf, Gap43, Coronin 1B, and Rab13 are downregulated in ANKRD11-deficient neurons. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
ANKRD11 | up-regulates activity
binding
|
TP53 |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266734 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 18840648 |
Ankyrin repeat domain 11, ANKRD11 (also known as ANR11 or ANCO1), was found to be a novel p53-interacting protein that enhanced the transcriptional activity of p53. In addition, ANKRD11 itself was found to be a novel p53 target gene. These findings demonstrate a role for ANKRD11 as a p53 coactivator and suggest the involvement of ANKRD11 in a regulatory feedback loop with p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ANKRD11
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