| + |
RNA_splicing | up-regulates 
|
messenger RNA |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268402 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32140746 |
The splicing of introns from nuclear precursors of message RNA (pre-mRNA) is executed by the spliceosome, a ribonucleoprotein (RNP) apparatus that first surfaced in the literature in 1985 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
U1 snRNP complex | up-regulates
|
RNA_splicing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270687 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30765414 |
The major spliceosomal building blocks are the U1, U2, U4/U6, and U5 small nuclear ribonucleoproteins (snRNPs). Each consists of a small nuclear RNA (snRNA) (or two, in the case of U4/U6), seven Sm proteins that form a ring (or seven Lsm proteins in the case of U6), and a variable number of snRNP-specific proteins (Fig. 1F) (Will and Lührmann 2011). Under splicing conditions, the U4/U6 and U5 snRNPs form a 25S U4/U6.U5 tri-snRNP, in which the U4 and U6 snRNAs are base-paired, forming a three-way junction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
U4/U6.U5 snRNP complex | up-regulates
|
RNA_splicing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270651 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30765414 |
The major spliceosomal building blocks are the U1, U2, U4/U6, and U5 small nuclear ribonucleoproteins (snRNPs). Each consists of a small nuclear RNA (snRNA) (or two, in the case of U4/U6), seven Sm proteins that form a ring (or seven Lsm proteins in the case of U6), and a variable number of snRNP-specific proteins (Fig. 1F) (Will and Lührmann 2011). Under splicing conditions, the U4/U6 and U5 snRNPs form a 25S U4/U6.U5 tri-snRNP, in which the U4 and U6 snRNAs are base-paired, forming a three-way junction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
U2 snRNP complex | up-regulates
|
RNA_splicing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270676 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30765414 |
The major spliceosomal building blocks are the U1, U2, U4/U6, and U5 small nuclear ribonucleoproteins (snRNPs). Each consists of a small nuclear RNA (snRNA) (or two, in the case of U4/U6), seven Sm proteins that form a ring (or seven Lsm proteins in the case of U6), and a variable number of snRNP-specific proteins (Fig. 1F) (Will and Lührmann 2011). Under splicing conditions, the U4/U6 and U5 snRNPs form a 25S U4/U6.U5 tri-snRNP, in which the U4 and U6 snRNAs are base-paired, forming a three-way junction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RNA_splicing