Relation Results

Summary

Name Lewy_body_formation
Primary ID SIGNOR-PH56
Type phenotype
Description Process that results in the formation of cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein
Relations 3
Pathways Parkinson

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Type: Score: Layout: SPV 
0.70.70.7Lewy_body_formationApoptosisSNCAIPSNCA

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Relations
Regulator
Mechanism
target
score ℹ
+ Lewy_body_formationup-regulates img/indirect-activation.png Apoptosis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-249703 Homo sapiens Neuron
pmid sentence
The genetic causes of PD seem to participate in con­ verging pathways to pathogenesis, but it is unclear whether all or only some of these pathways need to be activated for lewy body deposition and neuronal death to occur.
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson
+ SNCAIPup-regulates img/indirect-activation.png Lewy_body_formation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-272596 Homo sapiens
pmid sentence
Synphilin-1 interacts in vivo with α-synuclein, and their coexpression promotes the formation of Lewy body-like inclusions
Publications: 1 Organism: Homo Sapiens
+ SNCAup-regulates img/indirect-activation.png Lewy_body_formation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-249700 Homo sapiens
pmid sentence
A key observation linking alpha-synuclein to PD was the demonstration that it is one of the principal components of Lewy bodies. Furthermore, mutant isoforms of alpha-synuclein more readily oligomerize, and it has been suggested that its tendency to aggregate into misfolded structures may confer toxic properties to the protein.
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson
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