| + |
Lewy_body_formation | up-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249703 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20479780 |
The genetic causes of PD seem to participate in con verging pathways to pathogenesis, but it is unclear whether all or only some of these pathways need to be activated for lewy body deposition and neuronal death to occur. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Parkinson |
| + |
SNCA | up-regulates
|
Lewy_body_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249700 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12666095 |
A key observation linking alpha-synuclein to PD was the demonstration that it is one of the principal components of Lewy bodies. Furthermore, mutant isoforms of alpha-synuclein more readily oligomerize, and it has been suggested that its tendency to aggregate into misfolded structures may confer toxic properties to the protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Parkinson |
| + |
SNCAIP | up-regulates
|
Lewy_body_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272596 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19224863 |
Synphilin-1 interacts in vivo with α-synuclein, and their coexpression promotes the formation of Lewy body-like inclusions |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Lewy_body_formation