3.0
Summary
| Name |  SNCAIPView Modifications |
| Full Name | Synphilin-1 |
| Synonyms | Sph1, Alpha-synuclein-interacting protein |
| Primary ID | Q9Y6H5 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GSK3B | down-regulates 
phosphorylation
|
SNCAIP | 0.5 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SIAH1 | down-regulates
ubiquitination
|
SNCAIP | 0.662 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SIAH2 | down-regulates
ubiquitination
|
SNCAIP | 0.604 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKN | up-regulates quantity by stabilization 
ubiquitination
|
SNCAIP | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SNCAIP | up-regulates activity
binding
|
SNCA | 0.794 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF19A | up-regulates quantity
ubiquitination
|
SNCAIP | 0.465 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SNCAIP | up-regulates 
|
Lewy_body_formation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |