| + |
SERPINE1 | down-regulates 
|
Fibrinolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19387897 |
Plasma PAI-1 levels robustly fluctuate in a circadian manner and consequently contribute to hypofibrinolysis during the early morning. The circadian expression of PAI-1 gene is thought to be directly regulated by the circadian clock proteins such as CLOCK and BMAL1/BMAL2 which drive the endogenous biological clock. Plasma PAI-1 levels are increased in the beginning of the active phase in both diurnal humans and in nocturnal rodents, suggesting that the rhythmic PAI-1 expression is commonly indispensable for organisms. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68481 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10368279 |
Pai-1 is the physiological inhibitor of the fibrinolytic pathway |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
PLG | up-regulates 
|
Fibrinolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1447176 |
The conversion of plasminogen to plasmin can occur by several different mechanisms, but it appears that the most important in uiuo activator is tPA (2). tPA, M, = 70,000, is present in plasma as a single-chain serine protease, but proteolytic cleavage of the Agr275-Ile276 bond in tPA by plasmin yields a disulfide-linked two-chain enzyme |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Fibrinolysis | down-regulates
|
Fibrin |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1447176 |
The fibrinolytic system is sequentially composed of plasminogen activation and fibrin degradation [1, 2]. Three distinct inhibitors of the fibrinolytic system that differently regulate these two steps are plasminogen activator inhibitor type-1 (PAI-1), α2-antiplasmin (α2AP) and thrombin activatable fibrinolysis inhibitor (TAFI) [3]. PAI-1 limits the amount of free tissue-type plasminogen activator (tPA) both in plasma and on vascular endothelial cells (VECs), and regulates plasminogen activation potential to dissolve fibrin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Plasma |
3.0
Fibrinolysis