| + |
APOA1 | up-regulates 
|
HDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252110 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23077142 |
Cholesterol efflux is the first step in the formation of HDL, which is initiated through the action of ATP binding cassette transporter (ABC) A1 on apolipoprotein (apo) A-I that produces nascent HDL (nHDL). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABCG1 | up-regulates
|
HDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16054053 |
ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABCA7 | up-regulates
|
HDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265177 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14570867 |
Transfected ABCA7-GFP induced apolipoprotein-mediated assembly of cholesterol-containing HDL also in L929 cells, which otherwise generate only cholesterol-deficient HDL with their endogenous ABCA1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HDLBP | up-regulates
|
HDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266692 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9925647 |
HBP/vigilin binds HDL and apoA-I on ligand blots; conceivably therefore apoA-I may interact with cytoplasmic vigilin promoting changes in cholesterol flux. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABCA1 | up-regulates
|
HDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252109 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23077142 |
Cholesterol efflux is the first step in the formation of HDL, which is initiated through the action of ATP binding cassette transporter (ABC) A1 on apolipoprotein (apo) A-I that produces nascent HDL (nHDL). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HDL_assembly