| + |
MPO | down-regulates activity 
oxidation
|
APOA1 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20043647 |
When apolipoprotein A-I (apoA-I), the major HDL protein, was oxidized by MPO, its ability to promote cellular cholesterol efflux by ABCA1 was impaired. Moreover, oxidized apoA-I was unable to activate lecithin:cholesterol acyltransferase (LCAT), which rapidly converts free cholesterol to cholesteryl ester, a critical step in HDL maturation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SORT1 | up-regulates quantity 
binding
|
APOA1 |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273722 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 23283348 |
Here, we identified the pro-neurotrophin receptor sortilin as major endocytic pathway for clearance of APOE/Aβ complexes in neurons. Sortilin binds APOE with high affinity. Lack of receptor expression in mice results in accumulation of APOE and of Aβ in the brain and in aggravated plaque burden. Sortilin interacts with all human APOE isoforms. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
APOA1 | up-regulates 
|
HDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252110 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23077142 |
Cholesterol efflux is the first step in the formation of HDL, which is initiated through the action of ATP binding cassette transporter (ABC) A1 on apolipoprotein (apo) A-I that produces nascent HDL (nHDL). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOA1 | up-regulates activity
relocalization
|
APOE |
0.728 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252105 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20642861 |
ApoA-I stimulates apoE secretion in mature human adipocytes. The regulation of apoE secretion by apoA-I, is neither dependent upon an increase in gene transcription, nor upon increased release from the Golgi. It may therefore be assumed that, in macrophage models, apoE is stored mainly in the cytoplasm and/or on the cell surface, with apoA-I enabling secretion of this cytoplasmic pool |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK2 | up-regulates activity
|
APOA1 |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252107 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14668333 |
ApoA-I interactions with ABCA1 and lipid efflux to apoA-I were substantially impaired by inhibiting or abolishing JAK2, whereas ABCA1 protein levels were unaffected, and ABCA1 cholesterol translocase activity was only slightly reduced. The most likely explanation for these findings is that JAK2 promotes apolipoprotein interactions with ABCA1 or a closely proximal site, and this facilitates the removal of cellular lipids. the interaction of apolipoproteins with ABCA1-expressing cells activates JAK2, which in turn activates a process that enhances apolipoprotein interactions with ABCA1 and lipid removal from cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOA1 | up-regulates activity
|
JAK2 |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252108 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14668333 |
ApoA-I Stimulates JAK2 Autophosphorylation. the interaction of apolipoproteins with ABCA1-expressing cells activates JAK2, which in turn activates a process that enhances apolipoprotein interactions with ABCA1 and lipid removal from cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOA1 | up-regulates activity
binding
|
LCAT |
0.774 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19860440 |
Activation of LCAT by apolipoprotein (apo) A-I on nascent (discoidal) high density lipoproteins (HDL) is essential for formation of mature (spheroidal) HDL during the antiatherogenic process of reverse cholesterol transport. After attachment of LCAT to discoidal HDL, the helix 5/5 domains in apoA-I form amphipathic presentation tunnels for migration of hydrophobic acyl chains and amphipathic UC from the bilayer to the phospholipase A2-like and esterification active sites of LCAT, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOA1 | up-regulates
|
cholesterol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252104 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20642861 |
ApoA-I increases cholesterol release in mature human adipocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HP | up-regulates quantity by stabilization
binding
|
APOA1 |
0.723 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252106 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17824618 |
Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase. haptoglobin, when circulating at enhanced levels with free Hb during the acute phase of inflammation, might protect ApoA-I structure and function against hydroxyl radicals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABCA1 | up-regulates activity
binding
|
APOA1 |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15347662 |
The stimulation of cellular cholesterol and phospholipid efflux by apolipoprotein A-I is mediated by the activity of the ATP-binding cassette transporter A1 (ABCA1). ABCA1 forms a high affinity complex with apoA-I by binding amphipathic helices within the apolipoprotein. VFVNFA sequence is required for ABCA1 to form a complex with apoA-I and to transfer cholesterol to the apolipoprotein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOA1 | up-regulates quantity by stabilization
binding
|
ABCA1 |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252101 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12869555 |
ApoA-I stabilization of ABCA1 is mediated by reduced PEST sequence phosphorylation, which in turn leads to decreased calpain proteolysis of ABCA1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABCA7 | up-regulates activity
binding
|
APOA1 |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265178 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12917409 |
ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. HEK293 cells overexpressing ABCA7 showed specific binding and cross-linking of lipid-poor apoA-I. ABCA7 expression increased cellular phosphatidylcholine and sphingomyelin efflux to apoA-I in a manner similar to ABCA1 but had no effect on cholesterol efflux. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
APOA1
- 
- 