| + |
ERK1/2 | down-regulates
|
T-reg_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254686 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23620016 |
In the current study, addition of ERK inhibitors suppressed IL-6-induced RORgammat expression and promoted TGF-beta-induced Foxp3 expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254687 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21364186 |
Lowering the extent of costimulation of P2X in T cells diminishes the extent of ERK phosphorylation without affecting TCR-mediated nuclear translocation of NFAT (10). In Tregs, this mechanism would favor the stability of their transcriptional program through the stabilization of nuclear complexes of NFAT and Foxp3 (47). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXP3 | up-regulates
|
T-reg_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254970 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15785758 |
Viewed as a whole, the available data demonstrate essential involvement of Foxp3 in the development and function of CD4 + CD25 + T reg cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |