3.0
Summary
| Name |  FOXP3View Modifications |
| Full Name | Forkhead box protein P3 |
| Synonyms | Scurfin | IPEX |
| Primary ID | Q9BZS1 |
| Links |  -  -  |
| Type | protein |
| Relations | 16 |
| Pathways | Chemokines PDAC, T-lymphocytes: IL10 transcriptional regulation, T-Lymphocyte: IL10, T-Lymphocyte: TGF beta |
| Inhibitors | 2-hydroxyglutarate |
| Function | Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SCF-betaTRCP | down-regulates quantity by destabilization 
polyubiquitination
|
FOXP3 | 0.262 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GSK3B | down-regulates quantity by destabilization
phosphorylation
|
FOXP3 | 0.289 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | LCK | down-regulates
phosphorylation
|
FOXP3 | 0.412 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXP3 | up-regulates quantity by expression 
transcriptional regulation
|
CCL5 | 0.447 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXP3 | up-regulates quantity by expression
transcriptional regulation
|
CD274 | 0.483 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STAT3 | down-regulates 
|
FOXP3 | 0.592 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | DNMT1 | down-regulates quantity by repression
transcriptional regulation
|
FOXP3 | 0.503 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXP3 | up-regulates 
|
T-reg_differentiation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMAD3 | up-regulates
|
FOXP3 | 0.54 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | FOXP3 | up-regulates quantity by expression
transcriptional regulation
|
IL10 | 0.508 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 2-hydroxyglutarate | down-regulates activity
chemical inhibition
|
FOXP3 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STAT5A | up-regulates
|
FOXP3 | 0.496 |
| Publications: | 2 | Organism: | Homo Sapiens | |