MiR-142-3p downregulated MLL-AF4 expression in the RS4;11 leukemic cell line. the downregulation of MLL-AF4 by ectopically expressed miR-142-3p reduced the expression of MLL-AF4 downstream target genes, including HOXA7, HOXA9, and HOXA10, which may contribute to miR-142-3p-induced apoptosis and growth inhibition.