| + |
hsa-mir-146a-5p | down-regulates quantity by repression 
post transcriptional regulation
|
CD84 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279909 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 25743066 |
Cd84 was further tested for direct repression by miR-146a using luciferase reporter assays. This target was specifically repressed by miR-146a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-mir-146a-5p | down-regulates quantity by repression
post transcriptional regulation
|
SLAMF6 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279910 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 25743066 |
Luciferase assays, along with published reports, have shown that ectopic expression of miR-146a can lead to the repression of multiple mRNAs expressed by Tfh cells, including Slamf6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-mir-146a-5p | down-regulates quantity by repression
post transcriptional regulation
|
FERMT1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279891 |
|
|
Homo sapiens |
Keratocyte |
| pmid |
sentence |
| 28595995 |
Transfection of miR-146a suppressed the luciferase activity of reporters containing 3' UTR regions of FERMT1. Transfection of miR-146a suppressed the expression of endogenous FERMT1 at the mRNA level and, to a lesser extent, at the protein level, when stimulated with TNF-α, IFN-γ, or IL-17A. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-mir-146a-5p | down-regulates quantity by repression
post transcriptional regulation
|
IRAK1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279893 |
|
|
Homo sapiens |
Human Aortic Endothelial Cell |
| pmid |
sentence |
| 25623956 |
MiR-146a has anti-inflammatory action by directly targeting IRAK to inhibit NF-κB signaling, which exerts negative feedback control on the biogenesis of this miR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-mir-146a-5p | down-regulates quantity by repression
post transcriptional regulation
|
SLAMF1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279907 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 25743066 |
Slamf1 was further tested for direct repression by miR-146a using luciferase reporter assays. Therefore, Slamf1 is likely to be the novel direct target of miR-146a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-mir-146a-5p | down-regulates quantity by repression
post transcriptional regulation
|
ICOS |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279908 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 25743066 |
MiR-146a represses several Tfh cell-expressed messenger RNAs, and among these, ICOS is the most strongly autonomically upregulated target in miR-146a-deficient T cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
hsa-mir-146a-5p
