| + |
HOTAIR | up-regulates activity 
binding
|
DZIP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272091 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24326307 |
HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOTAIR | down-regulates 
|
MET |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32650779 |
LncRNA HOTAIR overexpression induced downregulation of c-Met signaling promotes hybrid epithelial/mesenchymal phenotype in hepatocellular carcinoma cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOTAIR | up-regulates activity
binding
|
MEX3B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272092 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24326307 |
HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
HOTAIR
