4.0
Satellite: IGF1R
Pathway ID: SIGNOR-ScIGF1R
Description: Insulin growth factor 1 (IGF1) plays an important role in modulating muscle regeneration. The stimulation of muscle growth through the activation of AKT/mTOR pathway has been well established and IGF1 is one important environmental stimulus that can enhance such a mechanism. IGF1 binds to its receptor and activates an intracellular cascade through the AKT pathway, leading to muscle cell growth.
Curated by: Alessandro Palma
Description: Insulin growth factor 1 (IGF1) plays an important role in modulating muscle regeneration. The stimulation of muscle growth through the activation of AKT/mTOR pathway has been well established and IGF1 is one important environmental stimulus that can enhance such a mechanism. IGF1 binds to its receptor and activates an intracellular cascade through the AKT pathway, leading to muscle cell growth.
Curated by: Alessandro Palma
15 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| CCN4 | O95388 |
| mTORC1 | SIGNOR-C3 |
| Muscle_atrophy | SIGNOR-PH40 |
| FBXO32 | Q969P5 |
| IRS1 | P35568 |
| Skeletal_muscle_differentiation | SIGNOR-PH1 |
| Cell_growth | SIGNOR-PH33 |
| CTNNB1 | P35222 |
| PI3K | SIGNOR-C156 |
| IGF1R | P08069 |
| RPS6K | SIGNOR-PF26 |
| IGF1 | P05019 |
| AKT | SIGNOR-PF24 |
| TRIM63 | Q969Q1 |
| FOXO1 | Q12778 |