| + |
STAT3 | up-regulates 
|
Cell_growth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252090 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11426647 |
Constitutive activation of Stat3 signaling is accompanied by upregulation of cyclin D1, c-Myc, and Bcl-x, changes consistent with subversion of normal cellular growth and survival control mechanisms. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EGFR Signaling, IL6 Signaling |
| + |
GLI1 | up-regulates
|
Cell_growth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235196 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3563490 |
The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
ELK1 | up-regulates
|
Cell_growth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-233471 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23426362 |
AR required ELK1 to up-regulate a major subset of its target genes that was strongly and primarily enriched for cell growth functions |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, Glioblastoma Multiforme, IL6 Signaling, Integrin Signaling |
| + |
OPTN | up-regulates
|
Cell_growth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259877 |
|
|
Mus musculus |
RGC-5 Cell |
| pmid |
sentence |
| 22194658 |
SiRNA effectively downregulated optineurin expression in RGC-5 and PC12 stable transfected cells. Optineurin siRNA significantly inhibited cell growth and increased apoptosis in RGC-5 and PC12 cells. Microarray analysis identified 112 differentially expressed genes in optineurin siRNA transfected RGC-5 cells. Quantitative real-time PCR and western blot confirmed that the expression of brain-derived neurotrophic factor (Bdnf), neurotrophin-3(Ntf3), synaptosomal-associated protein 25(Snap25), and neurofilament, light polypeptide(Nefl) was significantly downregulated in RGC-5 and PC12 cells transfected with optineurin siRNA. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CCNA1 | up-regulates
|
Cell_growth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249637 |
|
|
|
|
| pmid |
sentence |
| 15829981 |
Cyclin A1 contributes to G1 to S cell cycle progression in somatic cells. Cyclin A1 overexpression enhances S phase entry consistent with an oncogenic function. Finally, cyclin A1 might be a therapeutic target since its silencing inhibited leukemia cell growth. |
|
| Publications: |
1 |
| + |
mTORC1 | up-regulates
|
Cell_growth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209919 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
Cellular energy and nutrient status will dictate whether mTORC1 takes over and drives cell growth or conversely whether AMPK becomes active once again to drive consecutive waves of autophagy thorough ULK1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, EGFR Signaling, Glioblastoma Multiforme, Insulin Signaling, Luminal Breast Cancer |
3.0
Cell_growth