Name	FASLG
Full Name	Tumor necrosis factor ligand superfamily member 6
Synonyms	Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL \| APT1LG1, CD95L, FASL, TNFSF6
Primary ID	P48023
Links	- -
Type	protein
Relations	7
Pathways	COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS
Function	Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260).