Summary

Name FAS
Full Name Tumor necrosis factor receptor superfamily member 6
Synonyms Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor | APT1, FAS1, TNFRSF6
Primary ID P25445
Links - -
Type protein
Relations 16
Pathways COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS
Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding FAS 0.9
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS
+ up-regulates activity img/direct-activation.png binding RIPK1 0.635
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical
+ up-regulates activity img/direct-activation.png binding FAS 0.635
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FAS 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Liver
+ up-regulates img/indirect-activation.png DAXX 0.686
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RASSF1 0.261
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FAS 0.589
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates img/direct-activation.png binding MAP3K5 0.676
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding FAS 0.686
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FAS 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS
+ down-regulates img/indirect_inhibition.png FAS 0.399
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FAS 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FADD 0.906
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS
+ down-regulates img/indirect_inhibition.png FAS 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS