Summary

Name CASK
Full Name Peripheral plasma membrane protein CASK
Synonyms hCASK, Calcium/calmodulin-dependent serine protein kinase, Protein lin-2 homolog | LIN2
Primary ID O14936
Links - -
Type protein
Relations 5
Function Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).

Viewer

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding TBR1 0.474
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/indirect-activation.png Exocytosis 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CASK 0.474
Publications: 1 Organism: Homo Sapiens
Tissue: Cerebellum
+ img/unknown.png binding CASK 0.416
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CASK 0.845
Publications: 1 Organism: Chlorocebus Aethiops