+ |
CSNK1D | down-regulates quantity by destabilization
phosphorylation
|
MTSS1 |
0.333 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276611 |
Ser322 |
SSVSSHDsGFISQDA |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
24318128 |
Mechanistically, we defined that Casein Kinase Iδ (CKIδ) phosphorylates Ser322 to trigger MTSS1's interaction with β-TRCP for subsequent ubiquitination and degradation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SCF-betaTRCP | down-regulates quantity by destabilization
ubiquitination
|
MTSS1 |
0.324 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276610 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
24318128 |
Mechanistically, we defined that Casein Kinase Iδ (CKIδ) phosphorylates Ser322 to trigger MTSS1's interaction with β-TRCP for subsequent ubiquitination and degradation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTSS1 | up-regulates
binding
|
SUFU |
0.449 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-130545 |
|
|
Homo sapiens |
|
pmid |
sentence |
15545630 |
We found that in vitro translated gli1 and sufu bind to gst-mim, but not gst-mim?N399 Or gst columns (fig. 4f). Indicative of the importance of the mim/gli complex interactions, the mim?N399 Mutant that fails to interact with gli and sufu showed a markedly reduced capacity to potentiate gli-dependent transcription (fig. 4g). Although these results indicate that a mim/gli/sufu complex is important for mim-mediated transcriptional potentiation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Skin |
+ |
TBX5 | up-regulates quantity by expression
transcriptional regulation
|
MTSS1 |
0.252 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255254 |
|
|
Homo sapiens |
|
pmid |
sentence |
20802524 |
TBX5 suppressed tumor cell proliferation and metastasis through the upregulation of cyclin-dependent kinase inhibitor 2A, metastasis suppressor 1 and downregulation of synuclein gamma and metastasis-associated protein 1 family member 2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MTSS1 | up-regulates
binding
|
GLI1 |
0.524 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-130542 |
|
|
Homo sapiens |
|
pmid |
sentence |
15545630 |
Mim is a shh-responsive gene that can potentiate gli transcriptional activity.MIM Appears to regulate target gene expression through its association with the gli complex |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-157650 |
|
|
Homo sapiens |
|
pmid |
sentence |
17845852 |
Mim is a shh-responsive gene that can potentiate gli transcriptional activity.MIM Appears to regulate target gene expression through its association with the gli complex |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Tissue: |
Skin |
+ |
MTSS1 | up-regulates
binding
|
RAC1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-141573 |
|
|
Homo sapiens |
|
pmid |
sentence |
16280553 |
Mim-b binds and activates rac via its irsp53/mim domain |
|
Publications: |
1 |
Organism: |
Homo Sapiens |