| + |
TBX5 | up-regulates quantity by expression 
transcriptional regulation
|
NPPA |
0.575 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255384 |
|
|
Homo sapiens |
Heart |
| pmid |
sentence |
| 18451335 |
TBX5 is expressed, among others, in the embryonic heart and forelimbs.8 In the heart, it regulates transcription of downstream genes such as the atrial natriuretic factor (NPPA) and fibroblast growth factor 10 (FGF10) by the binding to T-box binding elements (TBEs),11 often in combination with the NKX2-5 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX5 | down-regulates quantity by repression 
transcriptional regulation
|
SNCG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255255 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20802524 |
TBX5 suppressed tumor cell proliferation and metastasis through the upregulation of cyclin-dependent kinase inhibitor 2A, metastasis suppressor 1 and downregulation of synuclein gamma and metastasis-associated protein 1 family member 2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX5 | up-regulates quantity by expression
transcriptional regulation
|
MTSS1 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255254 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20802524 |
TBX5 suppressed tumor cell proliferation and metastasis through the upregulation of cyclin-dependent kinase inhibitor 2A, metastasis suppressor 1 and downregulation of synuclein gamma and metastasis-associated protein 1 family member 2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX5 | up-regulates quantity by expression
transcriptional regulation
|
CDKN2A |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255253 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20802524 |
TBX5 suppressed tumor cell proliferation and metastasis through the upregulation of cyclin-dependent kinase inhibitor 2A, metastasis suppressor 1 and downregulation of synuclein gamma and metastasis-associated protein 1 family member 2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX5 | down-regulates quantity by repression
transcriptional regulation
|
MTA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255256 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20802524 |
TBX5 suppressed tumor cell proliferation and metastasis through the upregulation of cyclin-dependent kinase inhibitor 2A, metastasis suppressor 1 and downregulation of synuclein gamma and metastasis-associated protein 1 family member 2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NKX2-5 | up-regulates quantity by expression
transcriptional regulation
|
TBX5 |
0.795 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253650 |
|
|
|
|
| pmid |
sentence |
| 15095414 |
Mutation at the potential TBE-B and -C sites, and at the GC box and NKX2.5 sites significantly decreased luciferase activity, suggesting that the GC box and the potential TBE-B, -C, and NKX2.5 sites are functionally important for the activation of the promoter function. |
|
| Publications: |
1 |
| + |
TBX5 | up-regulates quantity by expression
transcriptional regulation
|
FGF10 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255383 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18451335 |
TBX5 is expressed, among others, in the embryonic heart and forelimbs.8 In the heart, it regulates transcription of downstream genes such as the atrial natriuretic factor (NPPA) and fibroblast growth factor 10 (FGF10) by the binding to T-box binding elements (TBEs),11 often in combination with the NKX2-5 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TBX5
- 
- 