Summary

Name RNGTT
Full Name mRNA-capping enzyme
Synonyms HCAP1, HCE | CAP1A
Primary ID O60942
Links - -
Type protein
Relations 2
Pathways mRNA maturation
Function Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.

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Relations

Regulator Mechanism target score ℹ
+ RNGTTup-regulates quantity img/indirect-activation.png chemical modification mRNA_capping 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:mRNA maturation, mRNA maturation
+ RNGTTup-regulates quantity img/direct-activation.png chemical modification messenger RNA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:mRNA maturation, mRNA maturation