| + |
RNGTT | up-regulates quantity 
chemical modification
|
mRNA_capping |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9512541 |
The human mRNA 5'-capping enzyme cDNA was identified. Three highly related cDNAs, HCE1 (human mRNAcappingenzyme1), HCE1A and HCE1B , were isolated from a HeLa cDNA library. The HCE1 cDNA has the longest ORF, which can encode a 69 kDa protein. A short region of 69 bp in the 3'-half of the HCE1 ORF was missing in HCE1A and HCE1B , and, additionally, HCE1B has an early translation termi |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
RNMT | up-regulates
|
mRNA_capping |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265503 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26942677 |
The creation of translation-competent mRNA is dependent on RNA polymerase II transcripts being modified by addition of the 7-methylguanosine (m7G) cap. The factors that mediate splicing, nuclear export, and translation initiation are recruited to the transcript via the cap. The cap structure is formed by several activities and completed by RNMT (RNA guanine-7 methyltransferase), which catalyzes N7 methylation of the cap guanosine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
mRNA_capping | up-regulates quantity by stabilization
chemical modification
|
messenger RNA |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268317 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19224921 |
Because only mRNA molecules that have been correctly spliced, capped at the 5′ extremity, and processed at the 3′ extremity can be used as templates for translation, processing of mRNA precursors plays a critical role in the regulation of gene expression. 3′ processing of pre-mRNAs comprises two steps (reviewed in Ref. 4): cleavage and polyadenylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
3.0
mRNA_capping