Relation Results

Summary

Name mRNA_capping
Primary ID SIGNOR-PH178
Type phenotype
Description The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts (GO:0036260).
Relations 3
Pathways mRNA maturation

Viewer

Type: Score: Layout: SPV 
0.70.70.7RNMTmRNA_cappingmessenger RNARNGTT

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ RNMTup-regulates img/indirect-activation.png mRNA_capping 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265503 Homo sapiens HeLa Cell
pmid sentence
The creation of translation-competent mRNA is dependent on RNA polymerase II transcripts being modified by addition of the 7-methylguanosine (m7G) cap. The factors that mediate splicing, nuclear export, and translation initiation are recruited to the transcript via the cap. The cap structure is formed by several activities and completed by RNMT (RNA guanine-7 methyltransferase), which catalyzes N7 methylation of the cap guanosine.
Publications: 1 Organism: Homo Sapiens
Pathways:mRNA maturation, mRNA maturation
+ mRNA_cappingup-regulates quantity by stabilization img/indirect-activation.png chemical modification messenger RNA 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268317 Homo sapiens
pmid sentence
Because only mRNA molecules that have been correctly spliced, capped at the 5′ extremity, and processed at the 3′ extremity can be used as templates for translation, processing of mRNA precursors plays a critical role in the regulation of gene expression. 3′ processing of pre-mRNAs comprises two steps (reviewed in Ref. 4): cleavage and polyadenylation.
Publications: 1 Organism: Homo Sapiens
Pathways:mRNA maturation, mRNA maturation
+ RNGTTup-regulates quantity img/indirect-activation.png chemical modification mRNA_capping 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268356 Homo sapiens
pmid sentence
The human mRNA 5'-capping enzyme cDNA was identified. Three highly related cDNAs, HCE1 (human mRNAcappingenzyme1), HCE1A and HCE1B , were isolated from a HeLa cDNA library. The HCE1 cDNA has the longest ORF, which can encode a 69 kDa protein. A short region of 69 bp in the 3'-half of the HCE1 ORF was missing in HCE1A and HCE1B , and, additionally, HCE1B has an early translation termi
Publications: 1 Organism: Homo Sapiens
Pathways:mRNA maturation, mRNA maturation
a simple tooltip