Summary

Name FZD7
Full Name Frizzled-7
Synonyms Fz-7, hFz7, FzE3
Primary ID O75084
Links - -
Type protein
Relations 8
Pathways Satellite: WNT
Function Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

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Relations

Regulator Mechanism target score ℹ
+ WNT11up-regulates activity img/direct-activation.png binding FZD7 0.701
Publications: 1 Organism: Drosophila Melanogaster
+ FZD7form complex img/form-complex.png binding FZD7/SDC4 0.54
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ WNT7Aup-regulates activity img/direct-activation.png binding FZD7 0.665
Publications: 3 Organism: , Homo Sapiens
Tissue: Skeletal Muscle, Muscle, Skeletal Muscle
+ FZD7up-regulates activity img/direct-activation.png binding GNAS 0.2
Publications: 1 Organism: Homo Sapiens
+ FZD7up-regulates img/direct-activation.png binding DVL1 0.647
Publications: 1
+ FZD7up-regulates activity img/indirect-activation.png RAC1 0.43
Publications: 1