The SIGnaling Network
Open Resource

Pathway ID: SIGNOR-ScWNT

Description: The WNT pathways are important signaling cascades initiated by several Wnt proteins, which are highly conserved across species. Here are represented the canonical and non-canonical pathways. Both signaling cascades play a pivotal role in muscle regeneration. In particular they are involved in muscle satellite cell proliferation and differantiation. The canonical pathway act through the accumulation of beta catenin, and its translocation into the nuscleus, where it favors the activation of MyoD to promote skeletal muscle differentiation. The non-canonical WNT pathway (also called "planar cell polarity pathway" PCP) leads to the symmetric expansion of muscle satellite cells. Extracellular matrix components can strongly affect muscle regeneration, being able to influence the maintenance of the overall satellite cell pool. Fibronectin activates the WNT non-canonical pathway, potentiating Wnt7a signaling through the Fzd7/Scd4 receptor complex which controls the regulation of satellite stem cell number.

Curated by: Simone Vumbaca