| + |
FN1/SDC4 | up-regulates 
|
WNT7A |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255287 |
|
|
|
|
| pmid |
sentence |
| 23290138 |
We found that binding of ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a to induce the symmetric expansion of satellite stem cells |
|
| Publications: |
1 |
| + |
WNT7A | up-regulates quantity by expression
transcriptional regulation
|
MMP10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278867 |
|
|
Homo sapiens |
5637 Cell |
| pmid |
sentence |
| 29549123 |
We first proved that Wnt7a activated the canonical Wnt pathway through direct regulation of the MMP10 gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT7A | up-regulates activity
binding
|
LRP5 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131900 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT7A | up-regulates quantity by expression
transcriptional regulation
|
MMP1 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278868 |
|
|
Homo sapiens |
5637 Cell |
| pmid |
sentence |
| 29549123 |
Because MMP1 is also another direct target of the canonical Wnt pathway (22), Wnt7a overexpression upregulated MMP1/10 to degrade the extracellular matrix and to facilitate UBC cell invasion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-127-5p | up-regulates quantity by expression
post transcriptional regulation
|
WNT7A |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278889 |
|
|
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 30867752 |
The results indicated that miR-127 inhibited GC progression by upregulating Wnt7a expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT7A | up-regulates activity
binding
|
FZD7 |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255845 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 23290138 |
Our previous work has demonstrated that ligation of Wnt7a to Fzd7 activates the planar cell polarity (PCP) pathway […] Therefore, we conclude that the Fzd7/Sdc4 co-receptor complex binds both Wnt7a and FN. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198919 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
Analysis of the expression of the fzd receptors during somitogenesis demonstrated that fzd7 is expressed in the hypaxial region of the somite, suggesting an interaction with wnt7a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255646 |
|
|
|
|
| pmid |
sentence |
| 23290138 |
Wnt7a-Fzd7 signaling stimulates symmetric stem cell divisions |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, |
| Tissue: |
Skeletal Muscle, Muscle, Skeletal Muscle |
| + |
WNT7A | up-regulates activity 
|
MYOD1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198922 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22944199 |
In explant cultures of mouse paraxial mesoderm, wnt1 induced expression of the mrf myf5, whereas wnt7a or wnt6 preferentially activated the mrf myod. Here we report that cells expressing wnt1 will preferentially activate myf5 while cells expressing wnt7a will preferentially activate myod |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60471 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9753670 |
Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5 |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
miR-370-3p | down-regulates quantity by repression 
post transcriptional regulation
|
WNT7A |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278866 |
|
|
Homo sapiens |
5637 Cell |
| pmid |
sentence |
| 29549123 |
Of note, the microRNA miR-370-3p directly repressed Wnt7a expression and thereby suppressed UBC cell invasion, which was partially restored by Wnt7a overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT7A | down-regulates 
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278875 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 31886205 |
Wnt7a Protein Inhibits Migration of HCC Cells by Downregulating EMT |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT7A | down-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278874 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 31886205 |
These results suggest that Wnt7a represses growth of liver cancer Hep3B cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278114 |
|
|
Homo sapiens |
NCI-H2122 Cell |
| pmid |
sentence |
| 15705594 |
Transfected Wnt-7a and Fzd-9 inhibit proliferation of NSCLC cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling |
| + |
WNT7A | up-regulates activity
binding
|
FZD3 |
0.648 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131897 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT7A | down-regulates quantity by repression
transcriptional regulation
|
SPRY4 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253034 |
|
|
Homo sapiens |
Non-small Cell Lung Cancer Cell |
| pmid |
sentence |
| 15705594 |
In NSCLC cells, Wnt-7a and Fzd-9 induced both cadherin and Sprouty-4 expression and stimulated the JNK pathway, but not beta-catenin/T cell factor activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT7A | up-regulates activity
|
PRKACA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176575 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Wnt1 and wnt7a stimulation of precursor cells activates protein kinase a (pka), which, through the phosphorylation of creb, induces the expression of the myogenic transcription factors myf5, myod and pax3, resulting in the myogenic commitment of embryonic precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT7A | down-regulates activity
binding
|
SKP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278876 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 31886205 |
These findings suggested that Wnt7a upregulated P21 and P27 by inactivating SKP2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT7A | up-regulates activity
binding
|
LRP6 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131903 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT7A | up-regulates activity
binding
|
Frizzled |
0.77 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253130 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
SOSTDC1 | down-regulates activity
|
WNT7A |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242710 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
WNT7A
- 
- 