3.0
Summary
| Name |  NCOR1View Modifications |
| Full Name | Nuclear receptor corepressor 1 |
| Synonyms | N-CoR, N-CoR1 | KIAA1047 |
| Primary ID | O75376 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Pathways | FAP: SIRT1 |
| Function | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | down-regulates 
phosphorylation
|
NCOR1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | down-regulates
phosphorylation
|
NCOR1 | 0.435 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SIRT1 | up-regulates 
|
NCOR1 | 0.641 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCOR1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG | 0.696 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCOR1 | down-regulates quantity by repression 
transcriptional regulation
|
SNAI2 | 0.362 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCOR1 | up-regulates activity
binding
|
BCL6 | 0.587 |
| Publications: | 1 | Organism: | Homo Sapiens | |