Summary

Name PIAS1
Full Name E3 SUMO-protein ligase PIAS1
Synonyms DEAD/H box-binding protein 1, Gu-binding protein, GBP, Protein inhibitor of activated STAT protein 1, RNA helicase II-binding protein | DDXBP1
Primary ID O75925
Links - -
Type protein
Relations 20
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png sumoylation FHL1 0.261
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png sumoylation SATB2 0.56
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png sumoylation AKT 0.388
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png sumoylation AKT1 0.388
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png sumoylation DDX5 0.521
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png sumoylation PRDM1 0.329
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIAS1 0.337
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PIAS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIAS1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png binding STAT1 0.784
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png sumoylation SMAD4 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png sumoylation RPA2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PIAS1 0.398
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png sumoylation TP53BP1 0.509
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding PIAS1 0.301
Publications: 1 Organism: Homo Sapiens