Summary

Name NTN1
Full Name Netrin-1
Synonyms Epididymis tissue protein Li 131P | NTN1L
Primary ID O95631
Links - -
Type protein
Relations 6
Pathways Axon guidance
Function Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).

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Relations

Regulator Mechanism target score ℹ
+ NTN1up-regulates activity img/direct-activation.png binding DCC 0.907
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance
+ NTN1up-regulates quantity img/direct-activation.png post transcriptional regulation ACTB 0.285
Publications: 1 Organism: Xenopus Laevis Laevis
Pathways:Axon guidance
+ NTN1up-regulates activity img/direct-activation.png binding NEO1 0.819
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance
+ NTN1up-regulates activity img/direct-activation.png binding DSCAM 0.724
Publications: 1 Organism: Mus Musculus
Pathways:Axon guidance
+ NTN1up-regulates img/direct-activation.png binding UNC5C 0.826
Publications: 1 Organism: Homo Sapiens
+ NTN1up-regulates activity img/direct-activation.png binding UNC5 0.849
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance