3.0
Summary
| Name |  BAG3View Modifications |
| Full Name | BAG family molecular chaperone regulator 3 |
| Synonyms | BAG-3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1 | BIS |
| Primary ID | O95817 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Function | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCD | up-regulates 
phosphorylation
|
BAG3 | 0.253 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERK1/2 | up-regulates activity
phosphorylation
|
BAG3 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CDK5 | down-regulates quantity by destabilization 
phosphorylation
|
BAG3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK3 | down-regulates quantity by destabilization
phosphorylation
|
BAG3 | 0.317 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXO22 | down-regulates quantity by destabilization
binding
|
BAG3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAG3 | down-regulates quantity by repression 
transcriptional regulation
|
SIRT5 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DNMT3B | up-regulates quantity by expression 
transcriptional regulation
|
BAG3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
ubiquitination
|
BAG3 | 0.283 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DNMT1 | up-regulates quantity by expression
transcriptional regulation
|
BAG3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAG3 | up-regulates activity
binding
|
HSPA8 | 0.78 |
| Publications: | 1 | Organism: | In Vitro | |