| + |
AKT | up-regulates 
phosphorylation
|
DNMT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244232 |
Ser143 |
RTPRRSKsDGEAKPE |
Homo sapiens |
|
| pmid |
sentence |
| 21151116 |
Akt1 kinase colocalizes and directly interacts with dnmt1 and phosphorylates ser143. Phosphorylated dnmt1 peaks during dna synthesis, before dnmt1 methylation. Depletion of akt1 or overexpression of dominant-negative akt1 increases methylated dnmt1, resulting in a decrease in dnmt1 abundance. In mammalian cells, phosphorylated dnmt1 is more stable than methylated dnmt1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates
phosphorylation
|
DNMT1 |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170530 |
Ser143 |
RTPRRSKsDGEAKPE |
Homo sapiens |
|
| pmid |
sentence |
| 21151116 |
Akt1 kinase colocalizes and directly interacts with dnmt1 and phosphorylates ser143. Phosphorylated dnmt1 peaks during dna synthesis, before dnmt1 methylation. Depletion of akt1 or overexpression of dominant-negative akt1 increases methylated dnmt1, resulting in a decrease in dnmt1 abundance. In mammalian cells, phosphorylated dnmt1 is more stable than methylated dnmt1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
DNMT1 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173677 |
Ser154 |
AKPEPSPsPRITRKS |
Homo sapiens |
|
| pmid |
sentence |
| 21565170 |
We report that cyclin-dependent kinases (cdks) 1, 2 and 5 can phosphorylate ser154 of human dnmt1 in vitro. Further evidence of phosphorylation of endogenous dnmt1 at position 154 by cdks is also found in 293 cells treated with roscovitine, a specific inhibitor of cdk1, 2 and 5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | up-regulates
phosphorylation
|
DNMT1 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173681 |
Ser154 |
AKPEPSPsPRITRKS |
Homo sapiens |
|
| pmid |
sentence |
| 21565170 |
We report that cyclin-dependent kinases (cdks) 1, 2 and 5 can phosphorylate ser154 of human dnmt1 in vitro. Further evidence of phosphorylation of endogenous dnmt1 at position 154 by cdks is also found in 293 cells treated with roscovitine, a specific inhibitor of cdk1, 2 and 5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5 | up-regulates
phosphorylation
|
DNMT1 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173685 |
Ser154 |
AKPEPSPsPRITRKS |
Homo sapiens |
|
| pmid |
sentence |
| 21565170 |
We report that cyclin-dependent kinases (cdks) 1, 2 and 5 can phosphorylate ser154 of human dnmt1 in vitro. Further evidence of phosphorylation of endogenous dnmt1 at position 154 by cdks is also found in 293 cells treated with roscovitine, a specific inhibitor of cdk1, 2 and 5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | down-regulates activity 
phosphorylation
|
DNMT1 |
0.291 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264788 |
Ser714 |
DNIPEMPsPKKMHQG |
in vitro |
|
| pmid |
sentence |
| 28143904 |
Together, these results indicate that AMPK phosphorylated DNMT1-Ser730, RBBP7-Ser314, and HAT1-Ser190|AMPK decreased DNMT1 activity |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRKAA1 | down-regulates activity
phosphorylation
|
DNMT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264783 |
Ser714 |
DNIPEMPsPKKMHQG |
in vitro |
|
| pmid |
sentence |
| 28143904 |
Together, these results indicate that AMPK phosphorylated DNMT1-Ser730, RBBP7-Ser314, and HAT1-Ser190|AMPK decreased DNMT1 activity |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
DNMT1 | up-regulates quantity by expression 
transcriptional regulation
|
BAG4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254112 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 18413740 |
In contrast, an increase in BAG-1, BAG-3, and BAG-4 gene expression was observed in HCT116 cells overexpressing either DNMT1 (DNMT1+) or DNMT3B (DNMT3B+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
5-azacytidine | down-regulates activity
chemical inhibition
|
DNMT1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259293 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585280 |
Both Azacitidine and Decitabine may also exert antitumor activity through induction of DNA hypomethylation, by forming a covalent complex with the major DNA methyltransferase (now termed DNMT1).Azacitidine and Decitabine effectively deplete the cell of functional DNA methylating activity, which results in profound hypomethylation after several rounds of DNA replication (Fig. 2). DNMT1 is considered a bona fide anticancer target at different levels |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU5F1 | up-regulates quantity by expression
transcriptional regulation
|
DNMT1 |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253158 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22795133 |
Oct4 and Nanog upregulate Dnmt1 through direct binding to its promoter, thereby leading to the repressed expression of p16 and p21 and genes associated with development and lineage differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC1 | down-regulates quantity by repression 
transcriptional regulation
|
DNMT1 |
0.779 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254028 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23242655 |
Our previous studies demonstrated that mutant p53 along with repression complex proteins including DNMT1, HDAC1 and MeCP2 is associated with ER-negative promoter in MDA-MB-468 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT1 | form complex 
binding
|
DNMT1/DNMT3B |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90839 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12145218 |
We show that the human de novo enzymes hdnmt3a and hdnmt3b form complexes with the major maintenance enzyme hdnmt1 /in vivo co-expression of hdnmt1 and hdnmt3a or hdnmt3b leads to methylation spreading in the genome, suggesting co-operation between de novo and maintenance enzymes during dna methylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
5-aza-2'-deoxycytidine | down-regulates activity
chemical inhibition
|
DNMT1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259294 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585280 |
Both Azacitidine and Decitabine may also exert antitumor activity through induction of DNA hypomethylation, by forming a covalent complex with the major DNA methyltransferase (now termed DNMT1).Azacitidine and Decitabine effectively deplete the cell of functional DNA methylating activity, which results in profound hypomethylation after several rounds of DNA replication (Fig. 2). DNMT1 is considered a bona fide anticancer target at different levels |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT1 | down-regulates quantity by repression
transcriptional regulation
|
FOXP3 |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269053 |
|
|
Homo sapiens |
Lymphocyte |
| pmid |
sentence |
| 32905139 |
Our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT1 | down-regulates quantity by repression
transcriptional regulation
|
ESR1 |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254027 |
|
|
Homo sapiens |
MDA-MB-468 Cell |
| pmid |
sentence |
| 23242655 |
Our previous studies demonstrated that mutant p53 along with repression complex proteins including DNMT1, HDAC1 and MeCP2 is associated with ER-negative promoter in MDA-MB-468 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NANOG | up-regulates quantity by expression
transcriptional regulation
|
DNMT1 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253157 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 22795133 |
Oct4 and Nanog upregulate Dnmt1 through direct binding to its promoter, thereby leading to the repressed expression of p16 and p21 and genes associated with development and lineage differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT1 | down-regulates quantity by repression
transcriptional regulation
|
GAD1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
RBBP7 | down-regulates activity
binding
|
DNMT1 |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264785 |
|
|
in vitro |
|
| pmid |
sentence |
| 28143904 |
AMPK inhibited DNMT1 through phosphorylation of Ser730 in DNMT1 and Ser314 in RBBP7|association with RBBP7 could inhibit DNMT1 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
DNMT1 | down-regulates quantity by repression
transcriptional regulation
|
MBD2 |
0.693 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254128 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 15618232 |
We then examined the levels of DNMT1 and methylated DNA-binding protein 2 (MBD2) expressions in these cells to determine whether this reduction in uPA expression is associated with changes in the DNA methylation machinery. Our results showed that ectopic expression of RAS induced DNMT1 expression and activity and inhibited MBD2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT1 | up-regulates quantity by expression
transcriptional regulation
|
BAG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254108 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18413740 |
DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT1 | form complex
binding
|
DNMT1/DNMT3A |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90836 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12145218 |
We show that the human de novo enzymes hdnmt3a and hdnmt3b form complexes with the major maintenance enzyme hdnmt1 /in vivo co-expression of hdnmt1 and hdnmt3a or hdnmt3b leads to methylation spreading in the genome, suggesting co-operation between de novo and maintenance enzymes during dna methylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT1 | down-regulates quantity by repression
transcriptional regulation
|
IL32 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254126 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 20889550 |
A virus or dsRNA in human PBMCs from healthy volunteers. We demonstrate that the NF-κB and CREB pathways play key roles in the activation of IL-32 production in response to influenza virus infection in A549 human lung epithelial cells.|Overexpression assays combined with RNA interference show that DNA methyltransferases DNMT1 and DNMT3b are critical for IL32 promoter methylation and gene silencing before viral infection. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | up-regulates activity
binding
|
DNMT1 |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264541 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12473678 |
Thus, these results indicate that MeCP2-interacting Dnmt1 has significant maintenance DNA methyltransferase activity and that MeCP2 does not vanish Dnmt1 enzymatic activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
DNMT1 | up-regulates quantity by expression
transcriptional regulation
|
BAG3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254110 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 18413740 |
In contrast, an increase in BAG-1, BAG-3, and BAG-4 gene expression was observed in HCT116 cells overexpressing either DNMT1 (DNMT1+) or DNMT3B (DNMT3B+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT1 | down-regulates quantity by repression
transcriptional regulation
|
RELN |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254575 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
3.0
DNMT1
- 
- 