| + |
GNAI2 | down-regulates 
|
Cell_invasion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278880 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 20054866 |
GNAI2 can significantly inhibit HCC cell migration and invasion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI2 | down-regulates
|
Cell_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278881 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 20054866 |
GNAI2 can significantly inhibit HCC cell migration and invasion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates activity 
binding
|
GNAI2 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148490 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16885213 |
Using this assay we determined that mouse Smo couples to all members of the Gi family but does not couple to those of other G protein families. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199162 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
it was proposed that Smo might signal through activation of Gi proteins to reduce PKA activity. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
GNAI2 | down-regulates activity
binding
|
ADCY6 |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278078 |
|
|
Spodoptera frugiperda |
SF-9 Cell |
| pmid |
sentence |
| 8119955 |
Types V and VI adenylyl cyclase are most sensitive to inhibition by Gnai1, Gnai2, and Gnai3 |
|
| Publications: |
1 |
Organism: |
Spodoptera Frugiperda |
| + |
CXCR4 | up-regulates activity
binding
|
GNAI2 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278103 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33073183 |
Using this model, we have reported that CXCL12 activates Gi1, Gi2, or Gi3 heterotrimeric G proteins in a concentration-dependent manner |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI2 | down-regulates activity
binding
|
ADCY1 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19703466 |
Adenylate cyclase is regulated by stimulatory hormones through Gs(alpha s beta gamma) and inhibitory hormones through Gi(alpha i beta gamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
GNAI2 | down-regulates activity
binding
|
ADCY5 |
0.524 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278075 |
|
|
Spodoptera frugiperda |
SF-9 Cell |
| pmid |
sentence |
| 8119955 |
Types V and VI adenylyl cyclase are most sensitive to inhibition by Gnai1, Gnai2, and Gnai3 |
|
| Publications: |
1 |
Organism: |
Spodoptera Frugiperda |
| + |
hsa-miR-30d-5p | down-regulates quantity by repression
post transcriptional regulation
|
GNAI2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278030 |
|
|
Homo sapiens |
SMMC-7721 Cell |
| pmid |
sentence |
| 20054866 |
MiR-30d Post-transcriptionally Down-regulates GNAI2 Expression by Directly Targeting Its 3' -UTR.| Taken together, these observations suggest that miR-30d is a positive metastatic regulator for HCC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI2 | down-regulates
binding
|
ADCY1 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37973 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8327893 |
Concentration-dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described. Activated Gi alpha but not G(o) alpha was effective, and myristoylation of Gi alpha was required |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
GNAI2 | down-regulates
binding
|
Adenylate_cyclase |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267849 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8327893 |
Concentration-dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described. Activated Gi alpha but not G(o) alpha was effective, and myristoylation of Gi alpha was required |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI2 | up-regulates activity
binding
|
TNFAIP8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256492 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20607800 |
TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-138-5p | down-regulates quantity by repression
post transcriptional regulation
|
GNAI2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278029 |
|
|
Homo sapiens |
SCC-4 Cell |
| pmid |
sentence |
| 21079996 |
Our data suggests that miR-138 directly targets the 3′-UTR of the GNAI2 mRNA. The down-regulation of miR-138 in TSCC resulted in increased expression of GNAI2 which led to enhanced cell proliferation and suppressed apoptosis in TSCC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GNAI2
- 
- 