Summary

Name BCR
Full Name Breakpoint cluster region protein
Synonyms Renal carcinoma antigen NY-REN-26 | BCR1, D22S11
Primary ID P11274
Links - -
Type protein
Relations 17
Function Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation YWHAQ 0.31
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation YWHAZ 0.336
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation BCR 0.376
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BCR 0.2
Publications: 4 Organism: Homo Sapiens, Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation BCR 0.376
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCR 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.579
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BCR 0.374
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation BCR 0.335
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination BCR 0.27
Publications: 1 Organism: Homo Sapiens