Relation Results

Summary

Name MYH1
Full Name Myosin-1
Synonyms Myosin heavy chain 1, Myosin heavy chain 2x, MyHC-2x, Myosin heavy chain IIx/d, MyHC-IIx/d, Myosin heavy chain, skeletal muscle, adult 1
Primary ID P12882
Links - -
Type protein
Relations 6
Function Muscle contraction.

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Type: Score: Layout: SPV 
0.20.20.20.3410.3850.356POU2F1MYH1TEKANGPT1MEF2DMEF2CMEF2A

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Relations
Regulator
Mechanism
target
score ℹ
+ POU2F1up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-238760 Mus musculus
pmid sentence
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ TEKup-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-241541 Mus musculus Myoblast
pmid sentence
the effects of the angiopoietins are not specific for vascular endothelial cells, as their receptors (Tie1, Tie2) are known to be expressed in hematopoietic cells and they have also recently been shown to be expressed in skeletal muscle cellsExogenous Ang-1 enhanced myogenic (MyoD and Myogenin) mRNA in differentiating myoblasts and increased myosin heavy chain protein.
Publications: 1 Organism: Mus Musculus
+ ANGPT1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-241560 Mus musculus Myoblast
pmid sentence
Exogenous Ang-1 enhanced myogenic (MyoD and Myogenin) mRNA in differentiating myoblasts and increased myosin heavy chain protein.
Publications: 1 Organism: Mus Musculus
+ MEF2Dup-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH1 0.341
Identifier Residue Sequence Organism Cell Line
SIGNOR-238751 Mus musculus
pmid sentence
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ MEF2Cup-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH1 0.385
Identifier Residue Sequence Organism Cell Line
SIGNOR-238754 Mus musculus
pmid sentence
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis
+ MEF2Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH1 0.356
Identifier Residue Sequence Organism Cell Line
SIGNOR-238748 Mus musculus
pmid sentence
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis
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