Summary

Name TEK
Full Name Angiopoietin-1 receptor
Synonyms Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p140 TEK | TIE2, VMCM, VMCM1
Primary ID Q02763
Links - -
Type protein
Relations 22
Inhibitors 4-[4-(6-methoxy-2-naphthalenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; N-[[3-fluoro-4-[[2-(1-methyl-4-imidazolyl)-7-thieno[3,2-b]pyridinyl]oxy]anilino]-sulfanylidenemethyl]-2-phenylacetamide; regorafenib
Function Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation TEK 0.2
Publications: 5 Organism: In Vitro, Mus Musculus, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TEK 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding TEK 0.525
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TEK 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition TEK 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.278
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding SHC1 0.557
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition TEK 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TEK 0.791
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.512
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding TEK 0.923
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.478
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding TEK 0.687
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.249
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition TEK 0.8
Publications: 1 Organism: Homo Sapiens