Relation Results

Summary

Name IRF2
Full Name Interferon regulatory factor 2
Synonyms IRF-2
Primary ID P14316
Links - -
Type protein
Relations 6
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and r ...
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Type: Score: Layout: SPV 
0.6990.520.20.6380.20.553IRF2BP1IRF2CIITATAP1IRF2BP2DSTSTAT1

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Relations
Regulator
Mechanism
target
score ℹ
+ IRF2BP1up-regulates activity img/direct-activation.png binding IRF2 0.699
Identifier Residue Sequence Organism Cell Line
SIGNOR-224045 Homo sapiens HeLa Cell
pmid sentence
We have identified two novel proteins that interact specifically with the C-terminal repression domain of Interferon Regulatory Factor-2 (IRF-2). These proteins, which we term IRF-2 binding proteins 1 and 2 (IRF-2BP1 and IRF-2BP2, the latter having two splicing isoforms, A and B), are nuclear proteins, and have the properties of IRF-2-dependent transcriptional co-repressors that can inhibit both enhancer-activated and basal transcription in a manner that is not dependent upon histone deacetylation.
Publications: 1 Organism: Homo Sapiens
+ IRF2up-regulates quantity by expression img/direct-activation.png transcriptional regulation CIITA 0.52
Identifier Residue Sequence Organism Cell Line
SIGNOR-271681
pmid sentence
In addition to IRF-1, IRF-2, another member of the IRF family, also activates the human CIITA type IV promoter, and IRF-2 cooperates with IRF-1 to activate the promoter in transient transfection assays.
Publications: 1
+ IRF2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TAP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254530 Homo sapiens
pmid sentence
We also show that this cytokine-dependent expression of TAP1 transcripts depends on STAT1 and IFN regulatory factor-2 (IRF-2), but not on IRF-1, and provide evidence that IRF-2 constitutively binds to the TAP1 gene promoter and enhances TAP1 promoter activity.
Publications: 1 Organism: Homo Sapiens
+ IRF2BP2up-regulates activity img/direct-activation.png binding IRF2 0.638
Identifier Residue Sequence Organism Cell Line
SIGNOR-224073 Homo sapiens HeLa Cell
pmid sentence
We have identified two novel proteins that interact specifically with the C-terminal repression domain of Interferon Regulatory Factor-2 (IRF-2). These proteins, which we term IRF-2 binding proteins 1 and 2 (IRF-2BP1 and IRF-2BP2, the latter having two splicing isoforms, A and B), are nuclear proteins, and have the properties of IRF-2-dependent transcriptional co-repressors that can inhibit both enhancer-activated and basal transcription in a manner that is not dependent upon histone deacetylation.
Publications: 1 Organism: Homo Sapiens
+ IRF2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DST 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254493 Homo sapiens
pmid sentence
Transient transfection studies with BPAG1 promoter-luciferase reporter gene plasmids and IRF1 and IRF2 expression plasmids revealed that IRF1 and IRF2 directly down-regulated BPAG1 gene transcription in cultured normal human epidermal keratinocytes.
Publications: 1 Organism: Homo Sapiens
+ STAT1up-regulates activity img/direct-activation.png binding IRF2 0.553
Identifier Residue Sequence Organism Cell Line
SIGNOR-254532 Homo sapiens
pmid sentence
We show that IRF-2 forms a complex with STAT1 and the cytokine-responsive region of the TAP1 promoter in any TPO or IFN-gamma target cells tested. Interaction of IRF-2 and STAT1 on the promoter depends on the DNA-binding domain of IRF-2.
Publications: 1 Organism: Homo Sapiens
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