Summary

Name IGFBP3
Full Name Insulin-like growth factor-binding protein 3
Synonyms IBP-3, IGF-binding protein 3, IGFBP-3 | IBP3
Primary ID P17936
Links - -
Type protein
Relations 5
Pathways Rett syndrome
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation IGFBP3 0.345
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Neuron_maturation 0.7
Publications: 1 Organism: Mus Musculus
Tissue: Brain
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IGFBP3 0.254
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Rett syndrome
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IGFBP3 0.2
Publications: 1 Organism: Homo Sapiens