+ |
CSNK2A1 | up-regulates quantity by stabilization
phosphorylation
|
IGFBP3 |
0.345 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250903 |
Ser138 |
PPAPGNAsESEEDRS |
Homo sapiens |
MCF-7 Cell |
pmid |
sentence |
10650937 |
The importance of Ser111 and Ser113 as targets for CK2 has also been shown in our laboratory, as mutation of either residue to alanine caused a major decrease in IGFBP-3 phosphorylation by this enzyme in vitro | These results indicate that IGFBP-3 interaction with acid-labile subunit and with the cell surface, both of which involve basic carboxyl-terminal residues, may be modulated by phosphorylation. Relative resistance to proteolysis and poor binding to cells suggest that CK2-phospho-IGFBP-3 may be a significant inhibitor of IGF activity in the extracellular environment. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250904 |
Ser140 |
APGNASEsEEDRSAG |
Homo sapiens |
MCF-7 Cell |
pmid |
sentence |
10650937 |
The importance of Ser111 and Ser113 as targets for CK2 has also been shown in our laboratory, as mutation of either residue to alanine caused a major decrease in IGFBP-3 phosphorylation by this enzyme in vitro | These results indicate that IGFBP-3 interaction with acid-labile subunit and with the cell surface, both of which involve basic carboxyl-terminal residues, may be modulated by phosphorylation. Relative resistance to proteolysis and poor binding to cells suggest that CK2-phospho-IGFBP-3 may be a significant inhibitor of IGF activity in the extracellular environment. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
IGFBP3 | down-regulates
|
Neuron_maturation |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265774 |
|
|
Mus musculus |
|
pmid |
sentence |
17278996 |
IGFBP3 overexpression due to lack of MeCP2 may lead to delayed brain maturation. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Tissue: |
Brain |
Pathways: | Rett syndrome |
+ |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
IGFBP3 |
0.254 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254580 |
|
|
Homo sapiens |
|
pmid |
sentence |
17278996 |
We found that MeCP2 directly regulates expression of insulin-like growth factor binding protein 3 (IGFBP3) gene in human and mouse brains. IGFBP3 overexpression was observed in the brains of mecp2-null mice and human RTT patients using real-time quantitative polymerase chain reaction and Western blot analyses. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Brain |
Pathways: | Rett syndrome |
+ |
SND1 | up-regulates quantity by expression
transcriptional regulation
|
IGFBP3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259140 |
|
|
Homo sapiens |
|
pmid |
sentence |
23878061 |
Therefore, we concluded that SND1 could affect SMMC-7721 cells proliferation by regulating IGFBP3 expression and IGF signaling pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |