| + |
GAMT | up-regulates 
|
Neuron_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265794 |
|
|
in vitro |
|
| pmid |
sentence |
| 26319512 |
GAMT enzyme (EC#2.1.1.2) deficiency caused by mutations in the GAMT gene (MIM# 601240) results in the depletion of creatine and accumulation of guanidinoacetate (GAA). Creatine has a buffering and transport function of high-energy phosphates in brain and muscle and is essential for growth cone migration, dendritic and axonal elongation, neurotransmitter release, and co-transmission on gamma amino butyric acid (GABA) postsynaptic receptors in the central nervous system |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Rett syndrome |
| + |
MECP2 | up-regulates
|
Neuron_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264968 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17532643 |
Our studies suggest that MeCP2 plays a central role in neuronal maturation, which might be mediated through epigenetic control of expression pathways that are instrumental in both dendritic development and synaptogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Hippocampus |
| Pathways: | Rett syndrome |
| + |
IGFBP3 | down-regulates 
|
Neuron_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265774 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17278996 |
IGFBP3 overexpression due to lack of MeCP2 may lead to delayed brain maturation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| Pathways: | Rett syndrome |
3.0
Neuron_maturation