4.0
Summary
| Name |  IGFBP3View Modifications |
| Full Name | Insulin-like growth factor-binding protein 3 |
| Synonyms | IBP-3, IGF-binding protein 3, IGFBP-3 | IBP3 |
| Primary ID | P17936 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | Rett syndrome |
| Function | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | up-regulates quantity by stabilization 
phosphorylation
|
IGFBP3 | 0.337 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | IGFBP3 | down-regulates 
|
Neuron_maturation | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Tissue: | Brain | |||
| Pathways: | Rett syndrome | |||
| + | SND1 | up-regulates quantity by expression 
transcriptional regulation
|
IGFBP3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MECP2 | down-regulates quantity by repression
transcriptional regulation
|
IGFBP3 | 0.251 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| Pathways: | Rett syndrome | |||