| + |
CYP11B2 | up-regulates quantity 
chemical modification
|
aldosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268685 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33117906 |
The zona glomerulosa lacks the 17alpha-hydroxylase enzyme, committing pregnenolone to the exclusive production of aldosterone.|In the adrenal steroidogenic pathway, 21-hydroxylase (P450c21) catalyzes the conversion of 17-hydroxyprogesterone (17OHP) to 11-deoxycortisol to form cortisol and the conversion of progesterone to 11-deoxycorticosterone to form aldosterone |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP11B2 | down-regulates quantity 
chemical modification
|
11-deoxycorticosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268681 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33117906 |
The zona glomerulosa lacks the 17alpha-hydroxylase enzyme, committing pregnenolone to the exclusive production of aldosterone.|In the adrenal steroidogenic pathway, 21-hydroxylase (P450c21) catalyzes the conversion of 17-hydroxyprogesterone (17OHP) to 11-deoxycortisol to form cortisol and the conversion of progesterone to 11-deoxycorticosterone to form aldosterone |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP11B2 | up-regulates quantity
chemical modification
|
cortisol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268676 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9814482 |
Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
APEX1 | down-regulates quantity by repression 
transcriptional regulation
|
CYP11B2 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253736 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22652909 |
We conclude that APEX1 is a novel transcriptional repressor of CYP11B2 and that differential APEX1 binding at -1651 of CYP11B2 results in altered gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR5A1 | down-regulates quantity by repression
transcriptional regulation
|
CYP11B2 |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254867 |
|
|
Homo sapiens |
NCI-H295R Cell |
| pmid |
sentence |
| 21169726 |
Inhibitory SF-1 was found to decrease the sensitivity of CYP11B2 and aldosterone to Ang II stimulation, whereas a down-regulation of SF-1 enhanced basal CYP11B2 expression and aldosterone production in H295R cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CYP11B2 | up-regulates quantity
chemical modification
|
18-hydroxycorticosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268684 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33117906 |
The zona glomerulosa lacks the 17alpha-hydroxylase enzyme, committing pregnenolone to the exclusive production of aldosterone.|In the adrenal steroidogenic pathway, 21-hydroxylase (P450c21) catalyzes the conversion of 17-hydroxyprogesterone (17OHP) to 11-deoxycortisol to form cortisol and the conversion of progesterone to 11-deoxycorticosterone to form aldosterone |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP11B2 | down-regulates quantity
chemical modification
|
11-deoxycortisol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268677 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9814482 |
Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
metyrapone | down-regulates activity
chemical inhibition
|
CYP11B2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257885 |
|
|
in vitro |
|
| pmid |
sentence |
| 21129965 |
In an effort to develop and evaluate new classes of compounds as CYP inhibitors, we based our investigations on the structure of the well-known CYP inhibitor Metyrapone 2, which has been used for the treatment of hypercortisolism and Cushing’ssyndrome for several decades. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CYP11B2 | up-regulates quantity
chemical modification
|
corticosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33117906 |
The zona glomerulosa lacks the 17alpha-hydroxylase enzyme, committing pregnenolone to the exclusive production of aldosterone.|In the adrenal steroidogenic pathway, 21-hydroxylase (P450c21) catalyzes the conversion of 17-hydroxyprogesterone (17OHP) to 11-deoxycortisol to form cortisol and the conversion of progesterone to 11-deoxycorticosterone to form aldosterone |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
3.0
CYP11B2
- 
- 