Summary

Name WT1
Full Name Wilms tumor protein
Synonyms WT33
Primary ID P19544
Links - -
Type protein
Relations 21
Pathways Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, AML-IDH/TET, IDH-TET in AML, NPM1_new
Function Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation WT1 0.346
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding WT1 0.456
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding WT1 0.467
Publications: 1 Organism: Homo Sapiens
Pathways:AML-IDH/TET, Acute Myeloid Leukemia, DNMT3A in AML, AML-IDH/TET, IDH-TET in AML, miRNA in AML, NPM1_new
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation WT1 0.625
Publications: 1 Organism: Mus Musculus
Pathways:Focal segmental glomerulosclerosis
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation REN 0.438
Publications: 1 Organism: Homo Sapiens
Pathways:Focal segmental glomerulosclerosis
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PAX2 0.625
Publications: 1 Organism: Mus Musculus
Tissue: Kidney
Pathways:Focal segmental glomerulosclerosis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DNMT3A 0.394
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, miRNA in AML
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOD1 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation AREG 0.406
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding WT1 0.518
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RBM4 0.378
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation WT1 0.464
Publications: 1 Organism: Mus Musculus
Pathways:Focal segmental glomerulosclerosis
+ up-regulates activity img/indirect-activation.png Urogenital_tract 0.7
Publications: 1 Organism: Mus Musculus
Pathways:Focal segmental glomerulosclerosis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC29A4 0.28
Publications: 1
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination WT1 0.2
Publications: 1
+ up-regulates img/direct-activation.png binding SRY 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation WT1 0.403
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PODXL 0.426
Publications: 1 Organism: Mus Musculus
Pathways:Focal segmental glomerulosclerosis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NPHS1 0.51
Publications: 1 Organism: Mus Musculus
Pathways:Focal segmental glomerulosclerosis
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:AML-IDH/TET, Acute Myeloid Leukemia, DNMT3A in AML, Onco-fusion proteins in AML, AML-IDH/TET, IDH-TET in AML, miRNA in AML, NPM1_new