Summary

Name TBP
Full Name TATA-box-binding protein
Synonyms TATA sequence-binding protein, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit | GTF2D1, TF2D, TFIID
Primary ID P20226
Links - -
Type protein
Relations 10
Function General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding TBP 0.407
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LIN28B 0.253
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TBP 0.735
Publications: 1 Organism: Oryctolagus Cuniculus
+ up-regulates activity img/direct-activation.png binding TBP 0.354
Publications: 1
+ form complex img/form-complex.png binding SL1 complex 0.736
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TBP 0.409
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TBP 0.419
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding TBP 0.895
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding TFIIIB 0.827
Publications: 1
+ form complex img/form-complex.png binding TFIID 0.887
Publications: 1 Organism: Homo Sapiens