| + |
TAF5 | form complex 
binding
|
TFIID |
0.897 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF2 | form complex
binding
|
TFIID |
0.885 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF10 | form complex
binding
|
TFIID |
0.896 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263926 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF11 | form complex
binding
|
TFIID |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263925 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBP | form complex
binding
|
TFIID |
0.893 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263933 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFIID | up-regulates activity 
relocalization
|
GTF2B |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269308 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8990153 |
Early in PIC assembly, TFIIA can associate with and stabilize the TFIID–DNA or the TFIIB–TFIID–DNA complexes, allowing them to ward off the deleterious effects of inhibitory negative cofactors and enhance the stimulatory effects of transcriptional activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF12 | form complex
binding
|
TFIID |
0.889 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFIID | up-regulates activity
relocalization
|
TFIIA |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8990153 |
PIC assembly begins with TFIID recognizing the TATA element, followed by coordinated accretion of TFIIB, the nonphosphorylated form of pol II (pol IIA) plus TFIIF, TFIIE, and TFIIH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
TAF13 | form complex
binding
|
TFIID |
0.874 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263923 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF9 | form complex
binding
|
TFIID |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263920 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF1 | form complex
binding
|
TFIID |
0.881 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263932 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF8 | form complex
binding
|
TFIID |
0.871 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263927 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF3 | form complex
binding
|
TFIID |
0.819 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263930 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF7 | form complex
binding
|
TFIID |
0.9 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF4 | form complex
binding
|
TFIID |
0.884 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263921 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAF6 | form complex
binding
|
TFIID |
0.911 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263922 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFIID | up-regulates activity
binding
|
POLR2A |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096372 |
Our structures suggest that a primary function of TFIID during PIC assembly is the proper positioning of TBP on the upstream promoter, which ultimately determines the placement of Pol II relative to the TSS. The structures presented here offer a structural framework for understanding the complex mechanism underlying TFIID function, shedding new light into the overlapping roles of TFIID as both a coactivator and a general platform for PIC assembly in the coordination of transcription initiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
4.0
TFIID
CPX-915