| + |
CDK5 | up-regulates activity 
phosphorylation
|
ERBB3 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250663 |
Ser1123 |
RSRSRSRsPRPRGDS |
Rattus norvegicus |
Cerebral Cortical Neuron |
| pmid |
sentence |
| 12824184 |
We demonstrated that Cdk5 phosphorylated Ser-1176 in the neuregulin receptor ErbB2 and phosphorylated Thr-871 and Ser-1120 in the ErbB3 receptor. We identified the Ser-1120 sequence RSRSPR in ErbB3 as a novel phosphorylation consensus sequence of Cdk5. Finally, we found that Cdk5 activity is involved in neuregulin-induced Akt activity and neuregulin-mediated neuronal survival. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250664 |
Thr873 |
LLYSEAKtPIKWMAL |
Rattus norvegicus |
Cerebral Cortical Neuron |
| pmid |
sentence |
| 12824184 |
We demonstrated that Cdk5 phosphorylated Ser-1176 in the neuregulin receptor ErbB2 and phosphorylated Thr-871 and Ser-1120 in the ErbB3 receptor. We identified the Ser-1120 sequence RSRSPR in ErbB3 as a novel phosphorylation consensus sequence of Cdk5. Finally, we found that Cdk5 activity is involved in neuregulin-induced Akt activity and neuregulin-mediated neuronal survival. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| + |
EGFR | up-regulates
phosphorylation
|
ERBB3 |
0.654 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34748 |
Tyr1276 |
GGGPGGDyAAMGACP |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 7929151 |
The erbb3 protein which possesses little or no intrinsic protein tyrosine kinase activiity is phosphorylated by the activated egf receptor protein tyrosine kinase on tyrosine residues within the yxxm sequence motif. These phosphorylated tyrosine residues interact with the p85 regulatory subunit of pi 3-kinase, which could result in the activation of the p110 catalytic subunit via a conformational mechanism. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34752 |
Tyr1289 |
CPASEQGyEEMRAFQ |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 7929151 |
The erbb3 protein which possesses little or no intrinsic protein tyrosine kinase activiity is phosphorylated by the activated egf receptor protein tyrosine kinase on tyrosine residues within the yxxm sequence motif. These phosphorylated tyrosine residues interact with the p85 regulatory subunit of pi 3-kinase, which could result in the activation of the p110 catalytic subunit via a conformational mechanism. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERBB3 | up-regulates
binding
|
PI3K |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252673 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16729043 |
Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sapitinib | down-regulates 
chemical inhibition
|
ERBB3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190155 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRG1 | up-regulates
binding
|
ERBB3 |
0.868 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26878 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 7514177 |
The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-4;and nrg-3 and nrg-4 bind erbb-4 direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26061 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7477375 |
The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-4;and nrg-3 and nrg-4 bind erbb-4 direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
ERBB3 | up-regulates
binding
|
PIK3CD |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16729043 |
Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST2 | down-regulates quantity by repression 
transcriptional regulation
|
ERBB3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255501 |
|
|
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 19051271 |
we performed microarray analysis to compare the gene expression profiles in HGC-27 cells, with or without small interfering RNA (siRNA)-mediated depletion of TWIST. Our results showed that NF1, RAP1A, SRPX, RBL2, PFDN4, ILK, F2R, ERBB3, and MYB were up-regulated, whereas AKR1C2, FOS, GDF15, NR2F1, ATM, and CTPS were down-regulated after TWIST depletion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EREG | up-regulates
binding
|
ERBB3 |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147856 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16829981 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191785 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22891299 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates
binding
|
ERBB3 |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99569 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12648465 |
Although ErbB-2 binds no known ligand, when recruited into heterodimers it increases ligand binding affinity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8816440 |
Although erbb-2 binds neither ligand, even in a heterodimeric receptor complex, it is the preferred heterodimer partner of the three other members, and it favors interaction with erbb-3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NRG2 | up-regulates
binding
|
ERBB3 |
0.814 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26881 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 7514177 |
Direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3.The neuregulins (also called heregulins and neu differentiation factors) nrg-1 and nrg-2 bind erbb-3 and erbb-4;and nrg-3 and nrg-4 bind erbb-4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRIG1 | down-regulates
ubiquitination
|
ERBB3 |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139951 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16123311 |
We report upregulation of lrig1 transcript and protein upon egf stimulation, and physical association of the encoded protein with the four egfr orthologs of mammals. Upregulation of lrig1 is followed by enhanced ubiquitylation and degradation of egfr. The underlying mechanism involves recruitment of c-cbl, an e3 ubiquitin ligase that simultaneously ubiquitylates egfr and lrig1 and sorts them for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB3 | up-regulates
binding
|
PIK3CA |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16729043 |
Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF41 | down-regulates quantity by destabilization
polyubiquitination
|
ERBB3 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272599 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12411582 |
Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB3 | up-regulates
binding
|
PIK3CB |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146864 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16729043 |
Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB3 | up-regulates
binding
|
PIK3CG |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146870 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16729043 |
Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB3 | up-regulates quantity by expression 
transcriptional regulation
|
AR |
0.52 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130443 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 15542423 |
Suspected erbb receptor involvement in prostate cancer originates partly from the realization that these proteins are capable of promoting the transcriptional activity of the androgen receptor (ar), her2/her3 effects on ar included effects on protein stability and stimulation of dna binding to ar target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB3 | up-regulates
binding
|
GRB2 |
0.832 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121971 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
All erbb ligands and receptors couple to activation of the ras-mapk pathway, either directly through sh2 domain-mediated recruitment of grb-2 or indirectly through ptb domain-mediated binding of the shc adaptor. In this study, we identify grb2 as a specific binding partner to tyrosines y1199 and y1268 of erbb3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146858 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16729043 |
All erbb ligands and receptors couple to activation of the ras-mapk pathway, either directly through sh2 domain-mediated recruitment of grb-2 or indirectly through ptb domain-mediated binding of the shc adaptor. In this study, we identify grb2 as a specific binding partner to tyrosines y1199 and y1268 of erbb3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
ERBB3
- 
- 