Summary

Name ERBB3
Full Name Receptor tyrosine-protein kinase erbB-3
Synonyms Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3 | HER3
Primary ID P21860
Links - -
Type protein
Relations 23
Inhibitors sapitinib
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation ERBB3 0.348
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation ERBB3 0.661
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ERBB3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination ERBB3 0.444
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation AR 0.517
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB2 0.834
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB3 0.574
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB3 0.813
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.71
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB3 0.572
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CD 0.396
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CG 0.329
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA 0.696
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination ERBB3 0.678
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CB 0.501
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB3 0.867
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle