3.0
Summary
| Name |  NR4A1View Modifications |
| Full Name | Nuclear receptor subfamily 4 group A member 1 |
| Synonyms | Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3 | GFRP1, HMR, NAK1 |
| Primary ID | P22736 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Function | Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | down-regulates activity 
phosphorylation
|
NR4A1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS6KA5 |
phosphorylation
|
NR4A1 | 0.391 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS6KA3 |
phosphorylation
|
NR4A1 | 0.477 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | down-regulates activity
phosphorylation
|
NR4A1 | 0.718 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS6KA2 | down-regulates activity
phosphorylation
|
NR4A1 | 0.376 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | MAPK8 | down-regulates
phosphorylation
|
NR4A1 | 0.515 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | up-regulates activity 
phosphorylation
|
NR4A1 | 0.659 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | NR4A1 | up-regulates quantity by expression 
transcriptional regulation
|
HSD3B2 | 0.372 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR3C1 | down-regulates quantity by repression 
transcriptional regulation
|
NR4A1 | 0.329 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR4A1 | down-regulates quantity by repression
transcriptional regulation
|
NR3C1 | 0.329 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RARA | down-regulates quantity by repression
transcriptional regulation
|
NR4A1 | 0.296 |
| Publications: | 1 | Organism: | Homo Sapiens | |