3.0
Summary
| Name |  RARAView Modifications |
| Full Name | Retinoic acid receptor alpha |
| Synonyms | RAR-alpha, Nuclear receptor subfamily 1 group B member 1 | NR1B1 |
| Primary ID | P10276 |
| Links |  -  -  |
| Type | protein |
| Relations | 32 |
| Pathways | Acute Myeloid Leukemia, ASXL1 in AML, Oxytocin signaling, Retinoic acid Signaling |
| Function | Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | down-regulates activity 
phosphorylation
|
RARA | 0.373 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | TFIIH |
phosphorylation
|
RARA | 0.275 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK7 | up-regulates 
phosphorylation
|
RARA | 0.521 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK7 |
phosphorylation
|
RARA | 0.521 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT | down-regulates
phosphorylation
|
RARA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML | |||
| + | AKT1 | down-regulates
phosphorylation
|
RARA | 0.58 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RARA | up-regulates quantity by expression 
transcriptional regulation
|
RXRG | 0.645 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RARA | up-regulates
binding
|
THRA | 0.402 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Oxytocin signaling | |||
| + | RXRA | up-regulates
binding
|
RARA | 0.704 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling | |||
| + | RARA | down-regulates quantity by repression 
transcriptional regulation
|
NR4A1 | 0.296 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RARA | down-regulates quantity by repression
transcriptional regulation
|
CCNA1 | 0.247 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML | |||
| + | ASXL1 | up-regulates quantity by expression
transcriptional regulation
|
RARA | 0.458 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML | |||
| + | RARA | up-regulates activity
binding
|
THR | 0.51 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | THRA | up-regulates
binding
|
RARA | 0.402 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Oxytocin signaling | |||
| + | RXRB | up-regulates
binding
|
RARA | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RARA | down-regulates quantity by repression
transcriptional regulation
|
EGFR | 0.411 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia | |||
| + | RARA | up-regulates quantity by expression
transcriptional regulation
|
SLCO1B3 | 0.2 |
| Publications: | 1 | |||
| + | all-trans-retinoic acid | up-regulates activity
chemical activation
|
RARA | 0.8 |
| Publications: | 2 | Organism: | Homo Sapiens, Chlorocebus Aethiops | |
| Pathways: | Acute Myeloid Leukemia, Retinoic acid Signaling | |||
| + | NCOA2 | up-regulates
binding
|
RARA | 0.61 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RARA | up-regulates
binding
|
THR | 0.51 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RARA | up-regulates
binding
|
RXRA | 0.704 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling | |||
| + | THR | up-regulates
binding
|
RARA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ASXL1 | up-regulates activity
binding
|
RARA | 0.458 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML | |||
| + | RARA | up-regulates
binding
|
RXRG | 0.645 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | THR | up-regulates activity
binding
|
RARA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
RARA | 0.69 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML | |||
| + | 9-cis-retinoic acid | up-regulates activity
chemical activation
|
RARA | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RARA | down-regulates
|
CTNNB1 | 0.385 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, Retinoic acid Signaling | |||
| + | KMT2E | up-regulates activity
binding
|
RARA | 0.346 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RARA | up-regulates quantity by expression
transcriptional regulation
|
OXT | 0.258 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Oxytocin signaling | |||