| + |
ETS1 | up-regulates quantity by expression 
transcriptional regulation
|
TNC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261599 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15001984 |
Sp1 and Ets1 are potent transactivators of the TN-C promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
A9/b1 integrin |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253312 |
|
|
Homo sapiens |
Macrophage, Synovial Fibroblast |
| pmid |
sentence |
| 24241034 |
Synovial fibroblasts and macrophages derived from arthritic joints spontaneously secreted tenascin-C and osteopontin. Synovial fibroblasts and macrophages obtained from patients with RA expressed α9β1 integrins, a common receptor for osteopontin and tenascin-C. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281328 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19838819 |
Cells can interact with tenascin-C via cell-surface receptors including integrins α2β1,α7β1, α9β1 and αvβ3, syndecans 1 and 4, annexin II, and epidermal growth factor receptor (EGFR) amongst others (Fig. 1, Table 1). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
Av/b6 integrin |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281323 |
|
|
Homo sapiens |
Epithelial Cell Line |
| pmid |
sentence |
| 25793576 |
Integrin αvβ6 is an epithelial-specific integrin that is a receptor for fibronectin (FN), vitronectin (VN), TNC, and the latency-associated peptide (LAP) of transforming growth factor (TGF)-β. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
SDC1 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281331 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19838819 |
Cells can interact with tenascin-C via cell-surface receptors including integrins α2β1,α7β1, α9β1 and αvβ3, syndecans 1 and 4, annexin II, and epidermal growth factor receptor (EGFR) amongst others (Fig. 1, Table 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
TNC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261600 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 15001984 |
Sp1 and Ets1 are potent transactivators of the TN-C promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
a7/b1 integrin |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281327 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19838819 |
Cells can interact with tenascin-C via cell-surface receptors including integrins α2β1,α7β1, α9β1 and αvβ3, syndecans 1 and 4, annexin II, and epidermal growth factor receptor (EGFR) amongst others (Fig. 1, Table 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | down-regulates activity 
binding
|
FN1 |
0.602 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282606 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11731446 |
We identified the antiadhesive mechanism as a specific interference of tenascin-C with cell binding to the HepII/syndecan-4 site in fibronectin through direct binding of tenascin-C to the 13th fibronectin type III repeat (FNIII13). Cell adhesion and proliferation levels were restored by the addition of FNIII13. Overexpression of syndecan-4, but not syndecan-1 or -2, reverted the cell adhesion defect of tenascin-C. We characterized FNIII13 as the binding site for syndecan-4. Thus we describe a novel mechanism by which tenascin-C impairs the adhesive function of fibronectin through binding to FNIII13, thereby inhibiting the coreceptor function of syndecan-4 in fibronectin-induced integrin signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
Av/b3 integrin |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277736 |
|
|
Homo sapiens |
Pancreatic Adenocarcinoma Cell Line |
| pmid |
sentence |
| 38058842 |
TNC is shown to bind to integrin receptors expressed in adjacent PAAD cells, thereby inducing EMT. In addition, TNC expression in CAFs had significant positive correlations with ITGαV, ITGβ1, or ITGβ3 expression in cancer cells, which supports our speculations that the TNC-integrin signaling axis promotes the EMT pathway in cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
A8/b1 integrin |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253306 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 7559467 |
The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
A2/b1 integrin |
0.454 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281326 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19838819 |
Cells can interact with tenascin-C via cell-surface receptors including integrins α2β1,α7β1, α9β1 and αvβ3, syndecans 1 and 4, annexin II, and epidermal growth factor receptor (EGFR) amongst others (Fig. 1, Table 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
ANXA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281329 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19838819 |
Cells can interact with tenascin-C via cell-surface receptors including integrins α2β1,α7β1, α9β1 and αvβ3, syndecans 1 and 4, annexin II, and epidermal growth factor receptor (EGFR) amongst others (Fig. 1, Table 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
SDC4 |
0.496 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19838819 |
Cells can interact with tenascin-C via cell-surface receptors including integrins α2β1,α7β1, α9β1 and αvβ3, syndecans 1 and 4, annexin II, and epidermal growth factor receptor (EGFR) amongst others (Fig. 1, Table 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNC | up-regulates activity
binding
|
Av/b1 integrin |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277735 |
|
|
Homo sapiens |
Pancreatic Adenocarcinoma Cell Line |
| pmid |
sentence |
| 38058842 |
TNC is shown to bind to integrin receptors expressed in adjacent PAAD cells, thereby inducing EMT. In addition, TNC expression in CAFs had significant positive correlations with ITGαV, ITGβ1, or ITGβ3 expression in cancer cells, which supports our speculations that the TNC-integrin signaling axis promotes the EMT pathway in cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
TNC
- 
- 